The price comparisons are for Xenical (120mg) in quantities of 90 and 270 pills at the online pharmacies which do not require a consultation fee. If you find these prescription diet pills at another pharmacy at a lower quoted price then it is likely that they are making up for the price with a processing fee or by charging for the online patient consultation when you buy online.

XENICAL may be right for you to buy if you have a Body Mass Index of 30 or greater, or have a BMI of 27 or greater and have other risk factors, such as high blood pressure, high cholesterol, heart disease or diabetes. Click here to calculate your BMI and find out if you might be a candidate for Xenical.

Did You Know? - Xenical interferes with your body's absorption of some fat-soluble vitamins. Therefore, when you use the prescription weight loss medicine Xenical, you should take a daily multivitamin supplement that contains vitamins D, E, and K and beta carotene. Take your multivitamin once a day at least 2 hours before or after taking Xenical, such as at bedtime.

CLINICAL PHARMACOLOGY (How Xenical works ....Technically)

Orlistat (Xenical) is a reversible inhibitor of lipases. It exerts its therapeutic activity in the lumen of the stomach and small intestine by forming a covalent bond with the active serine residue site of gastric and pancreatic lipases. The inactivated enzymes are thus unavailable to hydrolyze dietary fat in the form of triglycerides into absorbable free fatty acids and monoglycerides. As undigested triglycerides are not absorbed, the resulting caloric deficit may have a positive effect on weight control. Systemic absorption of the drug is therefore not needed for activity. At the recommended therapeutic dose of 120 mg three times a day, orlistat inhibits dietary fat absorption by approximately 30%. (If that was a mouth-full, so to speak, read below for the english version)

How Xenical Works (in English)

Unlike other prescription weight-loss drugs you may have heard about that act in the brain or central nervous system to suppress appetite or to speed up metabolism, Xenical works in your digestive system to block about one-third of the fat in the food you eat from being digested.

Enzymes in your digestive system, called lipases, help digest (or break down) fat. When taken with meals, this weight loss medicine attaches to the lipases and blocks them from breaking down some of the fat you have eaten.

The undigested fat cannot be absorbed and is eliminated in your bowel movements. By working this way, these prescription diet pills help block about one-third of the fat in the foods you eat from being absorbed by your body.

Did You Know? - The chemical name for the prescription diet pill Xenical is Orlistat.

How to Take Xenical Diet Pills

The recommended dose for this prescription weight loss medicine is one 120-mg capsule by mouth with liquid at each main meal that contains fat. You should take these pills up to three times a day in conjunction with a reduced-calorie diet. Each time you take a Xenical diet pill, your nutritionally balanced meal should contain no more than about 30% of calories from fat. You should evenly divide your daily intake of fat, carbohydrates and protein over three main meals. Take this weight loss medicine during meals or up to 1 hour after a meal. If you occasionally miss a meal or have a meal without fat, you can omit your dose of Xenical. Doses above 120-mg three times daily have not been shown to provide an additional weight-loss benefit. You should try to follow a healthy eating plan while taking these prescription diet pills.

Xenical Contraindications/Warnings/Precautions

Xenical shouldn’t be taken if you are pregnant, nursing, have food absorption problems or reduced bile flow. If you are taking cyclosporine, speak to your doctor before you buy or take these diet pills. This weight loss medicine reduces the absorption of vitamins, therefore, it is recommended that you buy and take a daily multivitamin.

Xenical Side Effects

Because these diet pills work by blocking the absorption of dietary fat, it is likely that you will experience some changes in bowel habits. These bowel changes are a natural effect of blocking the fat from being absorbed. They generally occur during the first weeks of treatment; however, for some people they may continue for 6 months or longer while on these prescription diet pills. These changes may include gas with oily discharge, an increased number of bowel movements, an urgent need to have them, and an inability to control them, particularly after meals containing higher amounts of fat than are recommended. Sounds like fun huh?

Did You Know? - Xenical was approved by the FDA on April 23rd, 1999. You can get all the technical FDA information about Xenical right here from the FDA website.

Why You Might Decide to Buy Xenical

Excess weight has been proven to contribute to an increased risk of developing many medical problems, including high blood pressure, high cholesterol, heart disease, and diabetes. The consumption of excess fatty food and calories plays a significant role in the development of excess weight. While fat is an important component of a balanced diet, the consumption of excess fat contributes to excess body weight, since fat provides twice the number of calories per gram of weight as carbohydrates and protein. Reduction of dietary fat intake is one potential way of losing weight. This medicine may be right for you if you are considerably overweight (at least 30% above ideal weight or a body mass index of 30 or greater). You may also be able to buy these diet pills if you are overweight (at least 20% above ideal weight or a body mass index of 27 or greater) and also have other risk factors such as high blood pressure, high cholesterol, heart disease, or diabetes.t.

Who Should NOT Consider Using Xenical?

Those who: consistently have problems absorbing food (chronic malabsorption); or have gallbladder problems; or are pregnant or are breastfeeding a child; or have ever had an allergic reaction to orlistat or any of the inactive ingredients in Xenical should not buy this weight loss medicine.

Did You Know? - Approximately 58 million, or one-third of American adults are overweight or obese. Among adults, the incidence of obesity has increased from 25 to 32 percent in the last 10 years.

Make Sure your Doctor Knows if you are:

Allergic to any medicines, foods, or dyes; taking any other weight-loss medication; taking cyclosporine; taking any other medicines (including those not prescribed by your doctor); taking any dietary supplements, including herbal products; planning to become pregnant; or anorexic or bulimic.

Continued Use of Xenical

Patients should only stay on orlistat beyond three months if they have lost five percent of their body weight since beginning treatment. It is probably a good idea to only buy a one month supply of these diet pills to start out. To continue past six months, they must have lost ten percent of their body weight. Treatment should not usually continue beyond 12 months and never beyond 24 months.

Did you Know? - Xenical is licensed for weight management in over 100 countries around the world.

Xenical Trials

During the second year that Xenical was released after approval by the FDA, significantly less weight was regained in those patients who continued taking this weight loss medicine than in patients who switched to placebo (35 percent vs. 63 percent regain of lost weight). this medicine also reduced total cholesterol and LDL cholesterol levels, as well as mean systolic and diastolic blood pressure, compared to diet alone. The clinical trial showed that Xenical was well-tolerated. The most common side effects reported were non-systemic and primarily gastrointestinal. These effects generally occurred early in treatment and were self-limited and of short duration in most cases.

Xenical and Type 2 Diabetes

Treating type 2 diabetes who are overweight and obese with the weight loss medication, Xenical (orlistat), substantially improves glycaemic control, reduces the need for anti-diabetic medication and helps them lose weight according to new data being presented at the European Association for the Study of Diabetes (EASD) meeting in Glasgow on September 10, 2001. The results from the first of two studies showed that type 2 diabetes patients treated with these Xenical prescription diet pills had significantly improved glycaemic control, as shown by significant reductions in HbA]lc, fasting glucose, and post prandial glucose, leading to a reduction in the mean daily dose of anti-diabetic medication (sulphonylureas) required.

Xenical can Help Lower Blood Pressure

Results from a multicenter clinical trial headed by researchers at the University of Alabama at Birmingham (UAB) show that weight loss induced by Xenical® (orlistat) can significantly reduce elevated blood pressure in overweight people. The study investigated the effect of this prescription diet medicine on weight loss and blood pressure in patients with treated but inadequately controlled high blood pressure. Researchers found that those patients treated with Xenical experienced a significantly greater decrease in diastolic blood pressure compared with placebo and significantly greater weight loss. They also found that a greater percentage of patients who received these prescription diet pills obtained a significant blood pressure benefit by reducing their blood pressure to a normal level or by at least 10 points.

Did you Know? - Did you know prescription diet pills are tax deductible? It's true! Prescription medications are tax deductible while over-the-counter medications are not. For more visit www.irs.gov. When you get to this page type 'Prescription' into the search textbox at the top left of the page. After the new page comes up, click on the "Publications: What Medical expenses are deductible" link.

Xenical and Cardiovascular Health

According to a leading Canadian researcher, Xenical, in combination with a mild calorie-reduced diet can significantly reduce the risk of cardiovascular disease in obese patients. In clinical trials, patients on this weight loss medicine showed significant reductions in cholesterol, insulin and glucose levels, as well as in blood pressure, which are all important causes of cardiovascular disease.

Xenical Blocks Cholesterol Absorption

Washington University investigators have shown that the Xenical weight-loss drug, orlistat, can help prevent obese people from absorbing cholesterol from their food. "This is the first time that a medication has been shown to block the absorption of cholesterol," said Samuel Klein, M.D., the Danforth Professor of Medicine and Nutritional Science at Washington University School of Medicine in St. Louis. "The results from our study suggest that orlistat therapy in obese patients may have beneficial effect on blood cholesterol that are independent of its effects on body weight."

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